Tangential Flow Filtration (TFF) (776)

Product Family

Sartorius offers flexible tangential flow filtration (TFF) systems for process development and clinical trials up to commercial production batches.
The TFF portfolio can flex to accommodate individual requirements, with a range of options that includes cost-efficient multi-use systems or closed systems with single-use flow kits for bioburden reduced processing.

Benchtop to production scale from 100 mL to 200 L
Working membrane sizes from 10 cm² to 10 m²
Single-use and multi-use
Highly- to fully automated
Compliancy to cGMP available
Modular standard systems allow shorter lead times

Product Family

Study factors for manufacturability
Collect important information about the behaviour of the molecules in downstream processing already in an early stage
Automated, parallel trials
Up to 16 channels can be managed by one control station
Lowest process volumes
Small scale screening with 10 cm² membrane area | 5 mL recirculation volume
Flexibility of two different process scales
Mid-scale screening is also possible with Sartocon® Slice 50 which has 50 cm² membrane area

Product Family

Polyethersulfone membranes are designed for single-use applications applied in the biotechnological and pharmaceutical industries.

Product Family

Screen Type: ECOCut-Off: 10 kDa
Membrane Material: Polyethersulfone
Gamma sterilized and ready to use filter loop assembly that includes:

Self-Contained filter unit
Tubing with Opta® connectors
2 pressure domes
TMP control pinch valve
Disposable pump head

Product Family

The Hydrosart® high-performance membrane is a stabilized cellulose-based membrane optimized for biopharmaceutical process applications. It is stable across a broad pH range and extremely hydrophilic, making it virtually non-fouling and non-protein binding, which leads to high product yield and high sustained flux.
Self-Contained Unit (SCU): Pre-flushed, sterile and ready to use
Cut-Off: 300 kDa
Membrane Material: Hydrosart®
Channel Design: ECO
Connectors: AseptiQuik®

Product Family

The Hollow Fiber TFF Modules | Single-use Line offer a true single-use tangential flow filtration solution. A broad variety of different pore sizes and molecular weight cut-offs (MWCO) ensure a suitable solution for a wide range of processes. The scalability ranging from Lab- over Pilot- up to Process-scale increases flexibility in each stage of production. Hollow Fiber TFF Modules | Single-use are delivered gamma irradiated, fully integrity tested and therefore ready-to-use. Since, no cleaning is required you can save valuable time.

Product Family

The Steamer Line Hollow Fiber TFF Modules are designed for perfusion and aseptic applications. They are delivered gamma irradiated and ready to use and can be autoclaved.


Self-contained units

Autoclavable

Product Family

Sartocon^® 2 plus - 1.4404 or 1.4435 - stainless steel holder is optimized for the use with up to ten Sartocon^® or 2 Sartocube^® production scale Crossflow cassettes (max. 7 m²). It is designed for applications from 30 l to 1000 l volume.

Product Family

The family of Sartorius TFF filter holders features the latest advances in TFF design for full flexibility. This unique design within the Sartocon® family provides you with predictable performance from process volumes down to scaling studies or in daily lab work.

Product Family

Sartocon^® Slice Holder filter holder is designed for low to medium volume applications from 300 ml to 100 l and optimized for use with up to five Sartocon^® Slice Crossflow cassettes (0.1–0.5 m²). The filterholder can be sterilized by autoclaving or inline steaming.