CIMmultus® C4 HLD 80 mL cGMP Compliant (2 μm)

CIMmultus® is a unique and industry-proven line of pre-packed chromatographic monolithic columns featuring large flow-through channels, designed for working with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), virus-like particles and exosomes. CIMmultus® columns can be used as single-use disposable or multi-use columns.

Item No.: 
911.8136-2
Piece
1

*Custom/bulk order quotes are provided within 72 hours of request.

CIMmultus® Monoliths are reusable chromatography devices for scalable high-resolution purification of complex biological samples. Inside the custom designed housing is a single piece stationary phase with homogeneous channel size and surface chemistry. This stationary phase is designed to simplify method transfer from development into production.

Without the need for column packing, CIMmultus® Monoliths are ready for use out of the box.

This high-performance ion exchange column is primarily intended for fast and efficient purification of biomolecules such as large proteins, viruses and virus like particles through their ionic interaction with the monolith. The following information is being provided to ensure proper product care and optimal product performance.

C4 (butyl) high ligand density (HLD) features:

  • Strong hydrophobic interaction
  • Working range, pH 2–13
  • Binds molecules with predominantly positive charge, repels molecules a predominantly negative charge
  • Use for capture, intermediate, or polishing steps in either bind-elute or flow-through mode
  • High capacity for purification of virus and VLP particles, large proteins
  • Sanitizable with 1 M NaOH

Applications

  • Application
    8799045943904

Compliance Information

  • GMP Compliance
    8798996300384

Dimensions

  • Channel Size
    2 µm
  • Column Tube Length
    110 mm
  • Inner Diameter
    15 mm
  • Outer Diameter
    34 mm

General Specifications

  • Flow Rate
    40–400 mL/min | 30–300 cm/h | 0.5–5 CV/min

Materials of Construction

  • Materials of Construction
    • Poly(butyl methacrylate -co- ethylene dimethacrylate)
    • Poly(butyl methacrylate -co- ethylene dimethacrylate)
    • Poly(butyl methacrylate -co- ethylene dimethacrylate)
    • Poly(butyl methacrylate -co- ethylene dimethacrylate)
    • Poly(butyl methacrylate -co- ethylene dimethacrylate)
    • Poly(butyl methacrylate -co- ethylene dimethacrylate)
    • Poly(butyl methacrylate -co- ethylene dimethacrylate)
    • Poly(butyl methacrylate -co- ethylene dimethacrylate)
    • Poly(butyl methacrylate -co- ethylene dimethacrylate)

Operating Conditions

  • Maximum Operating Pressure
    2.0 MPa | 20 bar | 290 psi
  • Recommended Operating Temperature
    4 °C (39 °F) to 40 °C (104 °F)
  • pH Stability
    Working range 3–13, cleaning in place 1–14

Physicochemical Information

  • Bed Volume
    80 mL

Product Information

  • Brand
    8798958125664
  • Package Type
    8799066030688