iQue® Human Antibody Dependent Cellular Phagocytosis (ADCP) Kit

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iQue® Human Antibody Dependent Cellular Phagocytosis (ADCP) Kit
 

The iQue® Human Antibody Dependent Cellular Phagocytosis (ADCP) Kit enables high throughput identification of tumor elimination mediated by mAbs. The kit is designed for homogeneous labeling of target cancer cells using a green fluorescent dye, effector cell identification via (non-adherent or adherent) CD14+ labeling, as well as quantification of cell membrane integrity.

Post labeling of target and effector cells, customer test antibodies are added, inducing tumor clearance via their binding to encoded target cells and subsequent CD14+ effector cell binding and engulfment. Test antibodies bind to target cells through its Fab region and CD14+ effector cells binding via Fc region. The readout measures the number of CD14+ effector cells that are positive for the cell encoder dye. The CD14+ effector cells can only be positive for the cell encoder dye if they have phagocytosed target cells.

The iQue® Human ADCP Kit has been validated for use on the iQue® platform with BR and VBR configurations.

Note: This product is not returnable. If you have any issues with this product, please contact your Sartorius sales representative for assistance.

Pack Size
Price (USD):
$6,000.00
Item No.: 
BA-97109
Availability: 

*Custom/bulk order quotes are provided within 24 hours of request.

Key Benefits Perform high-throughput analysis: Validated reagents for rapid quantification of ADCP in 96 or 384-well plates

Obtain quantitative data: Generate reproducible and specific measurements of ADCP suitable for pharmacological analysis

Analyze multiple cell models: Assess ADCP on a variety of adherent or non-adherent target cells

Maximize productivity: Reduce time to answer with real time data analysis and novel visualization tools

This particular family includes no-wash/1-wash protocols save time, increase productivity and allow for miniaturization. Reagents and kits can be multiplexed to increase assay content and reduce sample requirements.

Applications

  • Application
    Antibody Characterization
  • Research Area
    • Antibody Discovery
    • Drug Discovery
    • Immuno-Oncology

Biological Information

  • Target
    Human

General Specifications

  • Laser Configuration
    Violet-Blue-Red

Product Information

  • Brand
    iQue®
  • Pack Size
    5 X 384 wells

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