Sartoclear® Depth Filter Cell Clarification and Contaminant Removal Technologies

<paragraph>Various device formats are available to serve you from first the steps, throughout clinical phases and up to large scale manufacturing while always keeping the same filter material.</paragraph><paragraph><bold>Applications:</bold></paragraph><bulletlist><bullet>Mammalian cell culture harvests</bullet><bullet>Microbial lysates</bullet><bullet>Removal of precipitates from sera and plasma</bullet><bullet>Particle and colloid removal from process intermediates</bullet><bullet>Media Filtration</bullet></bulletlist><table width="0"><thead><tr><td><paragraph><bold>Grade</bold></paragraph></td><td><paragraph><bold>Description</bold></paragraph></td><td><paragraph><bold>Application examples¹</bold></paragraph></td></tr></thead><tbody><tr><td><paragraph>DL90</paragraph></td><td><paragraph>Very coarse primary grade on top of a coarse secondary filter for filtrations with high solid concentrations</paragraph></td><td><paragraph>Primary clarification of mammalian cell cultures, insect cell cultures, microbial fermentations, vaccines</paragraph></td></tr><tr><td><paragraph>DL75</paragraph></td><td><paragraph>Pure cellulose pre-filter combined with a coarse secondary filter</paragraph></td><td><paragraph>Primary clarification of mammalian cell cultures, insect cell cultures, microbial fermentations, vaccines</paragraph></td></tr><tr><td><paragraph>DL60</paragraph></td><td><paragraph>Coarse primary grade with a secondary fine filtration grade for lower to moderate solid concentrations</paragraph></td><td><paragraph>Post-perfusion bioreactors, vaccines</paragraph></td></tr><tr><td><paragraph>DL20</paragraph></td><td><paragraph>Fine filtration grade combined with a standard bioburden reduction grade for the removal of particles</paragraph></td><td><paragraph>Post centrifuge mammalian cell cultures, post primary depth filtration, process precipitates</paragraph></td></tr><tr><td><paragraph>DL10</paragraph></td><td><paragraph>Fine filtration grade followed by an very tight secondary filter for the removal of high concentrations of small particles</paragraph></td><td><paragraph>Post centrifuge microbial (e.g. E. coli) lysates, post primary depth filtration step, process precipitates</paragraph></td></tr><tr><td colspan="3"><paragraph>¹ The listed examples are indicative and need to be confirmed by small scale tests</paragraph></td></tr></tbody></table><paragraph>&nbsp;</paragraph><paragraph><bold>Available Formats for Scale-up</bold></paragraph><paragraph><bold>Sartoclear^® Caps</bold> are easy to use screening devices that help you to find the best grade for your application. All packages contains 3 units of the same grade and come with plug-in Luer adapters for the easiest possible exchange of filters.</paragraph><paragraph><bold>Sartoclear^® Depth Filter Midscale Cassettes</bold> are developed for scale-up filtrations with volumes between five to 10 liters (depending on the cell density).</paragraph><paragraph><bold>Sartoclear^® Depth Filter Cassettes</bold> are single-use filtration devices especially designed for biopharmaceutical clarification applications. The unique modular devices provide linear scalability from small to large scale processes. Three different sizes allow for a seamless adaptation to different process fluid volumes.</paragraph><paragraph><bold>Sartoclear^® Depth Filter Lenticular Modules </bold>are stackable depth filters for use in stainless steel housings, which are often used in large scale manufacturing facilities for biologicals.</paragraph>