Sartocon® Hydrosart® Cassette

Tech Support Documents
Sartocon® Hydrosart® Cassette
 

Hydrosart® high performance membrane is a stabilized cellulose based membrane optimized for biopharmaceutical process applications. It is stable across a broad pH range and extremely hydrophilic, making it non-protein binding and virtually non-fouling.

  • Ultra-low protein adsorption
  • Easy cleaning
  • Higher yields
  • Long product life
  • Retains its performance even with repeated use without fouling or loss of retention

Item No.: 
3021447906E--SW
Piece
1

*Custom/bulk order quotes are provided within 72 hours of request.

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Hydrosart® E-Screen ultrafiltration cassettes are available in the following nominal molecular weight cutoffs:

  • 2 kD
  • 5 kD
  • 10 kD
  • 30 kD
  • 100 kD
  • 300 kD

Hydrosart® 300 kD main applications are:

  • Virus concentration and purification
    • Viral vectors: Lentivirus, Adenovirus, MVA, Vaccinia
    • Inactivated or attenuated viral vaccines: Influenza, RSV
    • Virus like particles, nanoparticles
    • Contaminant removal: DNA, HCP
  • Polysaccharide concentration
    • Conjugate vaccines: removal of unconjugated polysaccharides
  • Large protein concentration

Applications

  • Industry
    Pharma / Biotech

Compliance Information

  • Bacterial Endotoxins
    < 0.18 EU/mL as determined by the LAL test
  • Biological Reactivity
    All materials of this filter element meet the requirements of the current USP Biological Reactivity tests <88> for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).
  • Extractables
    The total amount of extractables is well below the limits established by the current USP unter "Sterile Water for Injection".

Dimensions

  • Filtration Area
    0.6 m²
  • Flow Channel Geometry
    Protein conc. >20% /or viscosity above.3cp

General Specifications

  • Cassette Format
    Sartocon Cassettes
  • Filter Format
    Cassettes

Materials of Construction

  • Integral Frame
    Polyvinylidene fluoride (PVDF)
  • Membrane Material
    Hydrosart®
  • Sealing Compound
    Silicone White (High chemical resistance)
  • Spacer
    Polypropylene (PP)

Operating Conditions

  • Maximum Inlet Pressure
    4 bar
  • pH Stability
    pH 2 – 14

Physicochemical Information

  • MWCO
    300 kDa
  • Non-Fiber Releasing
    This filter product complies with the title 21 of the Code of Federal Regulations (CFR), section 210.3(b)(6) and 211.72.

Product Information

  • Brand
    Sartocon®
  • Sartoflow® 20, 1.4435, F/R38/P26, DIN
    Sartoflow® 20, 1.4435, F/R38/P26, DIN
    Item no.
    179-2DD380260E

    The Sartoflow® 20 stainless steel holder with hydraulic is designed for TFF applications from 200 L to 2500 L volumes. The holder is optimized for use with 4 Sartocon® up to 20 Sartocube® production scale TFF cassettes (max. 14 m2). Typical applications of the Sartoflow® 20 system includes concentration and diafiltration of proteins, vaccines, antibodies, oligo nucleotides, endotoxin removal etc., cell harvesting and clarification processes.